Back Cover: Smart proteolysis samplers for pre‐lab bottom‐up protein analysis – Performance of on‐paper digestion compared to conventional digestion

DOI: 10.1002/sscp.202100062 The cover picture shows filter paper which is converted into a sample preparation unit for high-end bottom-up protein analysis. trypsin covalently bound to cellulose digests proteins enabling shotgun and targeted proteomics experiments from dried matrix spots. These paper-based smart proteolysis samplers allow instant starting at the moment of sampling with potential continuation during postal transport. sampler good stability (no activity loss least 4 months when refrigerated) proteolytic up 50–60% acting in solution